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VOL. 1, ISSUE 1 (2025)
Interaction of fluoroquinolones with biomolecules: Mechanisms, binding studies, and pharmacological implications
Authors
Yash Raj Mehta
Abstract
Fluoroquinolones are a class of broad-spectrum
antimicrobial agents widely used in clinical practice. This review explores the
molecular mechanisms underlying the interaction of fluoroquinolones with key
biomolecules, including DNA, proteins, and enzymes. Various biophysical and
biochemical techniques such as spectroscopy, calorimetry, and computational
modeling have been employed to elucidate their binding affinities, modes of
interaction, and conformational changes induced in target molecules. Results
indicate that fluoroquinolones primarily exert their antibacterial effect by
stabilizing DNA-enzyme complexes, leading to inhibition of bacterial DNA gyrase
and topoisomerase IV activities. Additionally, the review highlights the
pharmacological implications of these interactions, including drug efficacy,
resistance development, and toxicity profiles. Understanding the binding
characteristics and mechanistic pathways provides insights for designing
next-generation fluoroquinolones with improved therapeutic indices. This
comprehensive analysis bridges the gap between molecular interactions and
clinical outcomes, paving the way for enhanced antimicrobial strategies.
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Pages:19-23
How to cite this article:
Yash Raj Mehta "Interaction of fluoroquinolones with biomolecules: Mechanisms, binding studies, and pharmacological implications". World Journal of Chemistry, Vol 1, Issue 1, 2025, Pages 19-23
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